Goal

Combined GLP-1 satiety with GHRH-driven lean-mass preservation during weight reduction.

Peptides

Semaglutide, Tesamorelin

Why it works

GLP-1 receptor agonism drives caloric deficit through satiety while GHRH-analog signalling restores pulsatile GH to preserve lean mass and shift fat loss toward visceral depots.

How to use

  • Semaglutide — 0.25 mg weekly sc for 4 weeks → 0.5 mg for 4 weeks → 1.0 mg for 4 weeks → 1.7 mg for 4 weeks → 2.4 mg thereafter.
  • Tesamorelin — 2 mg once daily subcutaneous, evening.