Research stack

Epithalon + NAD+ Combined Longevity Protocol

Pineal-peptide short course paired with NAD+ cellular energy dosing.

Component peptides

A synthetic tetrapeptide derived from pineal-gland extract characterised in Russian gerontology research for telomerase-related and geroprotective effects.

NAD+

Nicotinamide adenine dinucleotide is a small-molecule cofactor rather than a peptide, but it is commonly grouped with longevity peptides and included here for reference. Studied for effects on cellular energy metabolism and sirtuin signalling.

Goal

Pineal-peptide short course paired with NAD+ loading for a combined longevity protocol.

Peptides

Epithalon, NAD+

Why it works

Epithalon supports telomerase induction and pineal-melatonin restoration while NAD+ fuels sirtuin activity and mitochondrial redox, targeting nuclear and mitochondrial longevity pathways concurrently.

How to use

Epithalon — 5-10 mg daily subcutaneous for 10-20 consecutive days per course.
NAD+ — 100-250 mg subcutaneous 2-3x weekly during a 4-week loading phase, then weekly maintenance; IV 250-500 mg is also referenced.

Last updated: 2026-09-15

Component peptides	Epithalon + NAD+
Duration reported	4 weeks
Cycle pattern	One 20-day epithalon course annually, with concurrent NAD+ loading
Difficulty	intermediate
Regulatory status	Research use only. None of these compounds is FDA-approved for combined use described.

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