Research stack

MOTS-c Mitochondrial Longevity Protocol

Mitochondrial-encoded peptide protocol for AMPK and mitokine signaling research.

Component peptides

A 16-amino-acid peptide encoded within the mitochondrial 12S rRNA gene, characterised in research on mitochondrial signalling, metabolic homeostasis, and exercise biology.

Goal

Mitochondrial-encoded peptide for AMPK and mitokine signalling in longevity contexts.

Peptides

MOTS-c

Why it works

MOTS-c is a mitochondrial-derived AMPK activator that acts as a mitochondrial-to-nuclear communication signal supporting metabolic and exercise capacity.

How to use

MOTS-c — 5-10 mg 2-3x weekly subcutaneous.

Last updated: 2026-09-15

Component peptides	MOTS-c
Duration reported	8 weeks
Cycle pattern	8 weeks on, 4 weeks off
Difficulty	foundational
Regulatory status	Research use only. None of these compounds is FDA-approved for combined use described.

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