Research stack

GHRH + GHRP Dual-Pulse for Lean Mass (Sermorelin + Ipamorelin)

Classic GHRH + GHRP pairing with the native GHRH(1-29) analog rather than modified GRF.

Component peptides

The 29-amino-acid N-terminal fragment of endogenous growth-hormone-releasing hormone. Historically approved as Geref for paediatric growth-hormone-deficiency diagnostics.

Ipamorelin

A pentapeptide growth-hormone secretagogue that binds the ghrelin/GHS-R1a receptor, reported as one of the most selective GH-releasers with minimal effect on cortisol or prolactin.

Goal

Classic GHRH + GHRP pairing using native sermorelin with ipamorelin.

Peptides

Sermorelin, Ipamorelin

Why it works

Simultaneous GHRH-receptor and GHS-R1a agonism produce a larger synergistic pituitary GH pulse than either alone while preserving endogenous pulsatility.

How to use

Sermorelin — 100-300 mcg per pulse, 1-2x daily subcutaneous, pre-bed.
Ipamorelin — 100-300 mcg per pulse, co-administered.

Last updated: 2026-09-15

Component peptides	Sermorelin + Ipamorelin
Duration reported	12 weeks
Cycle pattern	12 weeks on, 4 weeks off
Difficulty	foundational
Regulatory status	Research use only. None of these compounds is FDA-approved for combined use described.

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