Purpose
The peptides in this stack address two distinct aspects of the sleep research literature: sleep-architecture modulation (DSIP) and the nighttime growth-hormone pulse (sermorelin). Sermorelin is administered at bedtime because the endogenous GHRH pulse peaks during early slow-wave sleep, and preserving that timing is emphasised across the GH-secretagogue literature.
Component peptides
- DSIP — 100–500 mcg subcutaneously, in the evening before sleep in reported protocols.
- Sermorelin — 100–300 mcg subcutaneously at bedtime.
Timing & rotation
Community research writeups typically describe a single nightly administration of both peptides, approximately 60–90 minutes apart in the evening, over a 4-week course followed by a 4-week washout.
Reconstitution & math
- DSIP 5 mg vial in 2 mL BAC → 2,500 mcg/mL; 250 mcg dose = 0.10 mL = 10 units.
- Sermorelin 5 mg vial in 2 mL BAC → 2,500 mcg/mL; 200 mcg dose = 0.08 mL = 8 units.
Use the individual peptide calculators for other combinations.
Reported outcomes
Rodent EEG studies report increased delta-band activity with DSIP. Sermorelin studies in older adults report modest IGF-1 elevations and body-composition shifts with sustained nighttime administration. Human trial data on the specific combination are limited.
References
See the individual profiles for DSIP and Sermorelin.